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Weak link?

Before the discovery of DNA, it was not known what specific chemicals are the 'genes' that evolution theory refers to. Nor, therefore, was it known what specific chemical reactions correspond to the processes 'replication' or 'variation'. Nevertheless, there was, at that time, no weakness in the theory that random variation and natural selection have given rise to all adaptations in nature. In particular, at that time, there was no weakness in the theory that they gave rise to the earliest (?) adaptation, replication.

There still isn't. Discovering more details about one part of the story but not another has not introduced any weakness into our explanation of the latter.

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